الفهرس 
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Abstract
Hypoxic-ischemic injury considered to be an important cause of neonatal mortality and morbidity. We aimed to assess the value of DWI and ADC measurements for diagnosis and grading of HIE. In our study, 20 patients their age was ranging from 5to14 days after birth diagnosed clinically as HIE. Diffusion-weighted imaging detected HIE in this study with a high sensitivity compared to low sensitivity of conventional MR imaging.
According to the severity and duration of the hypoxic or ischemic event, the neonates were classified into two groups.
The first group included 7(35%) patients who had mild to moderate injury (WM injury as watershed area or periventricular).
The second group included 10(50%) patients who had severe injury; 3(15%) of them had only BGT injury, while 7(35%) patients had combined BGT & WM lesions. There was a significant difference between the two groups regarding their ADC values (p value = 0.001).
In this study, we found that an ADC value of ≤ 0.8 was detected as best sensitivity specificity cut off point for detecting severe ischemic brain tissue injury at any location.
In Conclusion, we found that the DWI is highly sensitive for detection. This is in addition to being a fast imaging sequence, easily interpreted, with no contrast administration. The combination of conventional weighted images and DWI improve diagnostic value of MR imaging for evaluation of HIE.
ADC values should always be interpreted in combination with visual analysis of both conventional and diffusion-wighted images, and timing of scan needs to be taken into consideration.