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Abstract Androgen receptor is one of the steroid nuclear receptors with structural similarity to estrogen and progesterone receptors , but its role in breast cancer still not well understood , especially in those with ER and PR negative disease which lacks the response to hormonal treatment. Many studies demonstrated the coexpression of AR and ER. with high percentage of AR expression among ER positive breast cancer patients. This retrospective study was done at clinical oncology department Menoufia University from January 2013 till December 2014. For a sample of patients with ER negative breast cancer. Formalin fixed and paraffin embedded blocks were gathered, clinical and pathological data were collected from medical records and analysed. The aims of this study were to detect the expression of AR by immunehistochemistry and its correlation with different clinical and pathological characteristics. The study included 56 patients of them 37 patients were triple negative breast cancer (TNBC) In this study AR was detected in 32% of patients with higher expression in patients with ER negative , HER2 positive (52%). AR positive tumors were associated with axillary nodal metastases and Her2 expression. In TNBC it was associated with advanced stage, nodal involvement and worse prognosis. While it was associated with better over all survival in ER –ve / HER2 +ve patients. Thus Immunohistochemical determination of AR status may provide additional information about prognosis of breast cancer, and could be therapeutic target in ER negative breast cancer. |