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العنوان
Preperation,spectroscopic characterization and
biological evaluation of metal complexes of
resorcinol thiosemicarbazone /
المؤلف
zalat, Heba gamal shaban.
هيئة الاعداد
باحث / هبه جمال شعبان زلط
مشرف / عبده سعد الطبل
مناقش / مشيرة محمد عبد الواحد
مناقش / سعيد طلبة محمد
الموضوع
Drugs - Structure-activity relationships.
تاريخ النشر
2017.
عدد الصفحات
195 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
الناشر
تاريخ الإجازة
16/1/2017
مكان الإجازة
جامعة المنوفية - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

Cu(II), Ni(II), Co(II), Cr(III), Zn(II), Cd(III), Fe(II) and Mn(II)
complexes of (2Z,2’E)-2,2’-((4,6-dihydroxy-1,3-phenylene)bis(ethan-1-
yl-1-ylidene))bis(hydrazinecarbothioamide) have been prepared and
characterized by element analysis, IR, UV-Vis spectra, magnetic moment,
conductances, 1H-NMR spectra and mass spectra, Thermal analyse (DTA
and TGA) and ESR measurments. The analytical and IR data show that,
the ligand behaves as neutral bidentate or dibasic tetradentate. Molar
conductances in DMF indicate that, the complexes are non-electrolytes.
ESRspectra of solid Cu(II) complexes at room temperature show axial
type (dx2-y2 ) with covalent bond character in an octadedral environment.
Some complexes showed inhibitory activity agtainst hepatocellular
carcinoma (HepG-2 cell line) compared with a standard drug (sorafenib).