الفهرس 
Chronic Liver Disease in Older PeopleOnly 14 pages are availabe for public view
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Abstract
The aim of the current study was to assess the effect of liver cirrhosis on cardiac and renal functions in elderly patients, after exclusion of cardiac and renal diseases, or any other disease that can affect both systems.
This study is a cross sectional study. The study included 100 male and female patients aged 60 years and above. Subjects have been recruited via purposive sampling from the inpatient Geriatrics and Gerontology department, Internal Medicine department, and the outpatient clinic of Geriatrics and Gerontology department in Ain Shams University hospitals. The study sample was divided into two groups:
group 1:
Fifty elderly patients sixty years old and above, diagnosed to have compensated chronic liver disease.
group 2:
Fifty elderly patients (both males and females) sixty years old and above, diagnosed to have decompensated chronic liver disease.
We excluded those with history of cardiovascular diseases (e.g. hypertension, ischemic heart disease, and heart failure), severe anemia, chronic kidney disease, and patients with diagnosis of hepatorenal syndrome.
Each participant was subjected to:
1. Detailed history taking.
2. Detailed clinical examination.
3. Diagnosis of chronic liver disease and its etiology.
4. Electrocardiography.
5. Echocardiography.
6. Assessment of renal function tests.
7. Renal arterial duplex study.
In this study, a comparison was done between patients with compensated cirrhosis and those with decompensated cirrhosis regarding, liver function tests, ECG & ECHO findings, renal function tests, and renal arterial duplex findings.
Comparison between the two groups for different parameters of cardiac functions showed that, patients with decompensated cirrhosis had higher heart rate, QTc interval, and QRS duration.
The ECHO findings in this study showed that, generally, cirrhotic patients have high right and left atrial diameters, and patients with decompensated cirrhosis had higher RAD than patients with compensated cirrhosis. The study confirmed that diastolic dysfunction is prevalent in cirrhotic patients. EF % was found to be significantly correlated to serum albumin level, total proteins, AST, total and direct bilirubin.
Regarding renal assessment in this study, cirrhotic patients had higher right and left RI. Decompensated cases had higher RI with a significant difference. MELD score was found to be significantly correlated with RI of both kidneys in compensated and decompensated groups. Creatinine clearance was found to be lower -with a significant difference- in patients with decompensated cirrhosis.