الفهرس 
Abstract
Formulation and in vitro evaluation of sustained release matrix tablets of atenolol prepared by direct compression techniqueOnly 14 pages are availabe for public view
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Abstract
The objective of part I was to develop a sustained release tablet formulations of Atenolol by employing different percent polymer (Kollidon SR (KSR)) (20, 30, 40, and 49%), with different types of diluents (spray dried lactose (SP.D.L), Avicel pH101 (AV), or Emcompress (EMS)) by direct compression technique. Flow properties and compressibility were studied for the powder of the prepared tablets. The possibility of interaction of drug with the utilized pharmaceutical excipients was investigated using Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC). The prepared tablets were evaluated for various parameters including weight variation, thickness, friability, hardness, and disintegration time. In vitro drug release study was carried out using different media (0.1N HCl, Phosphate buffer PH 7.2, and Distilled water (DW)). Part II deals with the study of terbutaline sulphate matrix tablets. The drug was formulated in sustained release tablets using KSR (40 and 60%) and various filler (SP.D.L, AV, and EMS). The FT-IR and DSC of terbutaline sulphate mixture with the formulation ingredients (KSR, SP.D.L, AV, or EMS) were studied to predict the interaction (if any) between the drug and additives. The formulated tablets were evaluated for mechanical and physical parameters including flow properties and compressibility, weight variation, thickness, friability, hardness, and disintegration time. Release properties were evaluated using different media (0.1N HCl, Phosphate buffer PH 7.2, and DW). Part III deals with the accelerated stability of formulae that gave the best sustained release of atenolol and terbutaline sulphate. The selected formulations were tested initially and at predetermined time intervals (1, 2, and 3 months) for their physical characteristics, and in vitro release profile which measured spectrophotometrically. Finally, part IV deals with the bioavailability in rabbits for two atenolol tablets formulations containing; 40% KSR with SP.D.L filler (formula A) which gave acceptable physical characteristic, best controlled drug release behavior and good stability, that was compared with formula containing SP.D.L filler without KSR (formula B) and commercial tablets (C). The bioequivalence of the formulations with that of the commercial tablets was assessed.