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Abstract Transient tachypnea of the newborn is the most common cause of neonatal respiratory distress, it is the disease of term and late preterm neonates. Approximately 1% of infants have some form of respiratory distress that is not associated with infection. Respiratory distress (RD)includes both respiratory distress syndrome (RDS) and transient tachypnea of the newborn. Of this 1%, approximately 33-50 % have transient tachypnea of the newborn, TTN is a self-limited disease.Risk factors for TTN include birth by cesarean section with elective or non-elective, male sex, family history of maternal asthma,lower gestational age, macrosomia and maternal diabetes.As the lung pulmonary circulation increases following the first breath, the fluid in the lungs is cleared thus interruption of this process of clearing fluid from the lungs may result in respiratory distress, The lungs in utero are constantly secreting fluid to aid lung growth and development. However the rate of lung fluid production and volume of fetal lung lumen decreases before birth. The mechanism for fluid absorption is triggered by neuroendocrine hormones, which cause lymphatic vessel dilatation. Several factors that have been proposed to affect sodium reabsorption, glucocorticoids, oxygen, catecholamines,thyroid hormones and surfactant have been investigated in this regard |