الفهرس 
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Abstract
Cinnamon extract (CE) and diazepam may have a protective role against stress-induced changes in salivary glands. Thus, this study was conducted to demonstrate and compare the possible biological impact of cinnamon extract versus diazepam upon submandibular salivary glands of stressed albino rats. Forty eight adult male albino rats, were divided randomly into 4 equal groups; negative control (I), group (II) in which rats were subjected to chronic restrained stress for 6 hours daily for 15 days. The rats of groups III and IV were handled as those of group II and concomitantly were received cinnamon oil extract or diazepam respectively. Half of the rats from each group were euthanized at 16thdays while the remaining rats were euthanized at 30th day. The obtained specimens from right submandibular salivary glands were prepared for staining with H&E and inducible nitric oxide synthase (iNOS) stains. The specimens from left submandibular salivary glands were used to demonstrate neurotrophine-3 (NT-3) gene expression via real time polymerase chain reaction (RT-PCR). The obtained data were tabulated, coded then analyzed using statistical package for social science (SPSS). Microscopically, control group revealed normal structural and architectural features of normal salivary glands. Groups II, III and IV showed variable atrophic changes of acini and ductal cells at 16th day examination period. While, at 30th days, examined salivary glands appeared nearly with normal histological features. The highest level of iNOS and NT-3 gene expression was observed in group II at the two examination period. Statistically, there were overall significant difference between all groups in relation to all studied parameters. Conclusion: Cinnamon extract could protect against or delay various histopathological and neurodegenerative disorders as it reduces the expression of NT-3. Also, it may be a valuable alternative for diazepam in management of stress- induced various effects on salivary gland.