الفهرس 
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Introduction: ANGPTL-2 is primarily secreted by adipose tissue. Increased circulating ANGPTL2 levels are closely related to adiposity, inflammation and systemic insulin resistance. is to assess the correlation between angiopoietin-like protein II (ANGPTL-2) and insulin resistance in type 2 DM cases and obese persons.
Materials and methods: a total 80 subjects were included in the study their mean age was 51±6 years old, and they were divided into four groups. group (I) Included 20 obese type 2 diabetic patients, group (II) Included 20 obese non-diabetic patients, group (III) Included 20 lean type 2 diabetic patients and group (IV) Included 20 lean non-diabetic subjects as control. All subjects in this study were subjected to full medical history taking, thorough physical examination, fundus examination, abdominal ultrasound, FPG, HbA1c, lipid profile, ALT, AST, Creatinine, BUN, HCV antibody, HBs Ag, Urinary protein creatinine ratio, HOMA IR, Serum ANGPTL-2 and hs-CRP.
Results: The present study showed that there was a high statistical significant difference between the studied groups (p-value<0.01), being the highest in group I (mean 12.6 ± 4.1 ng/ml) followed by group III (9.5±3.8 ng/ml), group II (7.6±3.2 ng/ml) and group IV (5.6±1.8 ng/ml).
Moreover, Serum ANGPTL-2 level was significantly higher in type 2 diabetic patients with diabetic retinopathy. Multivariable binary logistic regression analysis in the current study demonstrated that ANGPTL-2 was found to be an independent predictor for insulin resistance and T2DM but not for obesity.
Conclusion: ANGPTL-2 can be used as an independent predictor for insulin resistance and T2DM