الفهرس 
ContentsOnly 14 pages are availabe for public view
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Abstract
Multiple sclerosis is a chronic disease of the central nervous system characterized by wide range of pathologic changes including edema, inflammation, gliosis, demyelination, and remyelination. Conventional MRI plays a cornerstone role in diagnosis, characterization and follow-up of multiple sclerosis. Advanced MRI techniques give more specific data about the pathology of multiple sclerosis, allowing better assessment of the pathologic types of the disease, its prognosis and its response to treatment. Susceptibility weighted imaging, by detecting the central vein sign, can differentiate multiple sclerosis from other similar white matter lesions by detecting the perivenous distribution of multiple sclerosis plaques. MR spectroscopy, by its ability of detecting metabolites in the brain, is considered a good tool for predicting the disease phenotype and evaluating disease progression. Magnetization transfer imaging allows follow-up of the disease progression, at the level of the individual lesions (by ROI measurement of MTR) and at the whole brain changes (by mean MTR of the whole brain and whole brain MTR histogram study).