الفهرس | Only 14 pages are availabe for public view |
Abstract A number of new peptides as well as some of new cationic surfactant were synthesized. The structures of all synthesized compounds were proved on the basis on their spectral and analytical data; IR, 1H NMR and MS spectra which all agreed with the assigned structures. Some of the synthesized compounds were tested and evaluated their properties as surface active agent and for their biological activity. Stearic acid (1) was refluxed with concentrated sulfuric acid in absolute ethanol to give the ester derivative 2 in 90% yield which was reacted with hydrazine hydrate to give the corresponding hydrazide derivative 3 in 89 % yield By the same way, palmitic acid (4) was reacted with concentrated sulfuric acid in absolute ethanol to give the ester derivative 5 in 89% yield which was reacted with hydrazine hydrate to give the corresponding hydrazide derivative 6 in 91 % yield The hydrazide derivative 3 was stirred with sodium nitrite, the product was extracted in ethylacetate, the glycine ethyl ester hydrochloride (7) was added in the presence of triethyl amine, the corresponding monopeptide 8 was obtained after cooling in 82 % yield The monopeptide 8 was refluxed with hydrazine hydrate in absolute ethanol to give the corresponding hydrazide derivative 9 in 85 % yield The hydrazide derivative 9 was stirred with sodium nitrite, the product was extracted in ethylacetate, the glycine ethyl ester hydrochloride (7) was added in the presence of triethyl amine, the corresponding dipeptide 10 was obtained after cooling in 78 % yield The hydrazide derivative 6 was stirred with sodium nitrite, the product was extracted in ethylacetate, the glycine ethyl ester hydrochloride (7) was added in the presence of triethyl amine, the corresponding monopeptide 11 was obtained after cooling in 79 % yield The monopeptide 8 was refluxed with hydrazine hydrate in absolute ethanol to give the corresponding hydrazide derivative 9 in 88% yield The hydrazide derivative 12 was stirred with sodium nitrite, the product was extracted in ethylacetate, the glycine ethyl ester hydrochloride (7) was added in the presence of triethyl amine, the corresponding dipeptide 13 was obtained after cooling in 78 % yield The stearic hydrazide derivative 3 was stirred with sodium nitrite, the product was extracted in ethylacetate, the leucine methyl ester hydrochloride (14) was added in the presence of triethyl amine, the corresponding monopeptide 15 was obtained after cooling in 77 % yield The monopeptide 15 was refluxed with hydrazine hydrate in absolute ethanol to give the corresponding hydrazide derivative 16 in 80% yield The hydrazide derivative 16 was stirred with sodium nitrite, the product was extracted in ethylacetate, the leucine methyl ester hydrochloride (14) was added in the presence of triethyl amine, the corresponding dipeptide 17 was obtained after cooling in 79 % yield The palmitic hydrazide derivative 6 was stirred with sodium nitrite, the product was extracted in ethylacetate, the leucine methyl ester hydrochloride (14) was added in the presence of triethyl amine, the corresponding monopeptide 18 was obtained after cooling in 78 % yield The monopeptide 18 was refluxed with hydrazine hydrate in absolute ethanol to give the corresponding hydrazide derivative 19 in 82 % yield The hydrazide derivative 19 was stirred with sodium nitrite, the product was extracted in ethylacetate, the leucine methyl ester hydrochloride (14) was added in the presence of triethyl amine, the corresponding dipeptide 20 was obtained after cooling in 79 % yield The stearic hydrazide derivative 3 was stirred with sodium nitrite, the product was extracted in ethylacetate, the β-alanine methyl ester hydrochloride (21) was added in the presence of triethyl amine, the corresponding monopeptide 22 was obtained after cooling in 77 % yield The monopeptide 22 was refluxed with hydrazine hydrate in absolute ethanol to give the corresponding hydrazide derivative 23 in 78% yield The hydrazide derivative 23 was stirred with sodium nitrite, the product was extracted in ethylacetate, the tyrosine ethyl ester hydrochloride (24) was added in the presence of triethyl amine, the corresponding dipeptide 25 was obtained after cooling in 84 % yield The palmitic hydrazide derivative 6 was stirred with sodium nitrite, the product was extracted in ethylacetate, the β-alanine methyl ester hydrochloride (21) was added in the presence of triethyl amine, the corresponding monopeptide 26 was obtained after cooling in 77 % yield The monopeptide 26 was refluxed with hydrazine hydrate in absolute ethanol to give the corresponding hydrazide derivative 27 in 83 % yield The hydrazide derivative 27 was stirred with sodium nitrite, the product was extracted in ethylacetate, the β-alanine methyl ester hydrochloride (21) was added in the presence of triethyl amine, the corresponding dipeptide 28 was obtained after cooling in 84 % yield Compound 16 was sterried with chloroacetylchloride in anhydrous dichloromethane in the presence of trimethyl amine as a catalyst to give the compound 29 in 85% yield Compound 23 was sterried with chloroacetylchloride in anhydrous dichloro methane in the presence of trimethyl amine as a catalyst to afford the compound 30 in 80 % yield By the same way compound 27 was sterried with chloroacetylchloride in anhydrous dichloro methane in the presence of trimethyl amine as a catalyst to give the compound 31 in yield 84 % Compound 29 was sterried with trimethyl amine in tetrahydro furan to give the compound 32 in 85 % yield Compound 30 was sterried with trimethyl amine in tetrahydro furan to afford the compound 33 in 87 % yield Compound 31 was sterried with trimethyl amine in tetrahydro furan to afford the compound 34 in 81 % yield |