الفهرس 
Thalassemia ThalassemiaOnly 14 pages are availabe for public view
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Abstract
Beta-thalassemia results from the impaired production of beta-globin chains, leading to a relative excess of alpha-globin chains. The pathophysiology in patients with Beta-thalassemia is attributed to 3 main factors: ineffective erythropoiesis, chronic anemia and hemolysis, and primary iron overload. Aim of the work: To evaluate the prevalence of renal tubular dysfunction in children with Beta –thalassemia (B-T) major. Patients and methods: The study included 45 beta-thalassemic major patients who attending ElFayoumUnivesity Hospital. They include 21 male and 24 female, their ages ranges from 3 to 15 years. The study also enrolled 25 cases were taken as age &sex matched healthy controls.All patients (cases and control) were subjected to the following : Through history, complete examination and serum&urinary investigations. Results: increase urinary excretion of NAG in 55.6% of cases, increased urinary excretion of Ca in 26% of patients and uric acid excretion in 38% of patients, Serum levels of creatinine were higher in 40% of patients but still within normal range, Our results showed that 22.29% of patients were underweight , while 42.2% of patients were short stature. We found a positive correlation between urinary NAG and the followings (Serum ferritin, Serum creatinine, duration of the disease and urinary Ca / Cr ratio, also urinary NAG levels were higher in patients with splenectomy than in patients with splenomegaly.Conclusion: Our data confirm that glomerular and tubular dysfunctions exist in children with Beta-Thalassemia major .These abnormalities are not detected early, but with prolonged repeated tubule damage, tubulointerstitial fibrosis may occur