الفهرس 
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Abstract
Infertility is a common side effect of chemotherapy that bears a substantial impairment on the quality of life for young survivors of cancer. Doxorubicin is a very potent chemotherapeutic drug. Despite its efficiency, doxorubicin has been shown to cause death of healthy cells, especially those undergoing rapid proliferation. It has been shown that doxorubicin causes germ cell death and seminal alterations. The main pathogenic mechanism following exposure to DOX appears to involve the generation of reactive oxygen species.
There are many reports recommending that using of various antioxidants might be effective in alleviating DOX induced toxicities in different tissues. Spirulina platensis contains very potent naturally occurring antioxidant and free radical scavenging agents. One of the most important properties of Spirulina is its antioxidant activity. Very high amounts of beta-carotene, tocopherol and combined form of these antioxidants make Spirulina a very good source of natural antioxidant along with high protein. These antioxidants can protect the body from oxidative stress.
Therfore, the present study was delineated to evaluate the possible antioxidant and gonadoprotective effect of Spirulina platensis in doxorubicin treated rats.
For this purpose, forty adult male albino rats were randomly allocated into four equal groups as follow:
group I, Control group, received 0.5ml normal saline orally once daily for 5 weeks.