الفهرس 
Historic Background of G I STand Smooth Muscle NeoplasmOnly 14 pages are availabe for public view
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Abstract
Background: GIST was introduced as a diagnostic term in 1983. The understanding of GIST biology changed significantly with the identification of the molecular basis of GIST particularly c-KIT. The identification of a molecular basis for GIST led to the exclusion of many tumors that had been considered as GIST previously, and also the incorporation of a much larger number of tumors that had been labeled as other types of sarcomas and undifferentiated carcinomas. Aim of the Work: This essay is aimed to study gastrointestinal stromal tumor as regard what is it, what is the historic background, what is the clinical presentation, how it is diagnosed, what is the therapy for GIST, how the GIST is treated surgically, what is the role of surgical operations in the recurrent cases of GIST and what is the future therapy for GIST. Conclusion: Gastrointestinal stromal tumors (GISTs) is a neoplasm that arises in the smooth muscle pacemaker cells of Cajal. It is pathologically identified by a tyrosine kinase membrane receptor, c-kit protein (CD 117 antigen). Most (66%) occur in the stomach and gastric GISTs have a lower malignant potential than tumors found elsewhere in the GI tract (Miettinen and Lasota, 2006).