![]() | Only 14 pages are availabe for public view |
Abstract The introduction of gonadotrophin-releasing hormone (GnRH) analogues for pituitary suppression in vitro fertilization (IVF) significantly decreased the incidence of premature luteinizing hormone (LH) surge (premature luteinization PL), this refers to a rise in serum progesterone levels on the day of human chorionic gonadotrophin (hCG) administration. The absolute cutoff value of serum progesterone concentration on the hCG day to define premature elevation, with ranges from0.8 to 2 ng/ml. Several hypotheses have been proposed to explain the possible pathophysiology of PL, such as precocious elevation of follicular LH levels, serum accumulation of hCG or LH from hMG, and increased sensitivity of granulosa cell LH receptors to gonadotrophin. To establish whether there is a correlation between the pregnancy outcomes and serum progesterone levels in the follicular phase of ICSI cycles or not. This study analysed the correlation between the pregnancy outcomes and serum progesterone level in the follicular phase of ICSI cycles by serial measures of serum progesterone level. Also we found that there is a significant deference between both groups as regard number of MII oocytes, number of retrieved oocytes and number of embryo transferred. In our study we found no correlation between the clinical pregnancy and serum progesterone level in the follicular phase of ICSI cycles by serial measures of serum progesterone level. |