الفهرس 
pain
aim of the workOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Pain after surgery is common, often severe and largely unnecessary. Effective relief of post-operative pain is vital and not just humanitarian reasons, this study was concerning in comparing the effect and safety of an agonist-antagonist opioid analgesic drug (Nalbuphine) to the non-opioid IV infusion of Acetaminophen in the assessment of post-operative pain developed after lower abdominal surgery.
Objective: Assessment of pain relief and safety after administering a single dose of Acetaminophen intravenous infusion against a single dose of Nalbuphine intravenous injection after lower abdominal surgery.
Methods: One hundred male patients were divided in to two groups; each group of 50 patients subjected to lower abdominal surgery, first group was given 1g Acetaminophen intravenous infusion while the other group was given 10 mg Nalbuphine intravenous injection. The patients were educated to express their pain feelings in the form of marks on the visual analogue scale (VAS) sheet.
VAS readings were taken before giving both drugs (baseline), then after 15 min, 1hr, 2h, 3h and 4h from giving the drugs of study. The difference between both groups regarding VAS and the difference inside each group (to baseline) were statistically analyzed.
Blood glucose level was measured before giving drugs (baseline), then after 1h, 2h, 3h and 4h from giving the drugs of study. The difference between both groups regarding blood glucose level and the difference inside each group (to baseline) were statistically analyzed.
Heart rate and blood pressure were measured before giving both drugs, then after 1h, 2h, 3h and 4h from giving the drugs of study. The differences between both groups were statistically analyzed.
The need for any additional analgesia was recorded in both groups and statistically analyzed.
Finally, any side effects appeared as a result of the drugs of study were noticed and recorded.
Results: After 15 min and 1h from giving both drugs, there were no significant differences between Acetaminophen group and Nalbuphine group in lowering VAS recorded.
After 2h, 3h and 4h Nalbuphine lowered VAS readings in a significant way more than Acetaminophen.
While there were no significant difference regarding blood glucose level, heart rate and arterial blood pressure between both groups at all times of study.
Abstract
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Both groups needed additional analgesia, although the difference between both groups was statistically insignificant.
Both drugs almost showed no adverse effects.
Conclusion: This study concludes that both Acetaminophen IV infusion and Nalbuphine IV injection were effective and safe in relieving post-operative pain in male patients suspected to lower abdominal surgeries. However, Nalbuphine IV injection is more preferable than Acetaminophen IV infusion in relieving pain after lower abdominal surgeries as it’s efficacy in lowering VAS maintained until the end of the study time.