الفهرس 
Diabetic NephropathyOnly 14 pages are availabe for public view
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Abstract
Diabetic nephropathy is a major microvascular complication of diabetes mellitus and the most common cause of end stage renal disease worldwide. It has been proposed that inflammatory process seems to play an important role in the development of diabetes and its late complications (Ghosh et al., 2016). It is characterized by mesangial cell proliferation, extracellular matrix (ECM) accumulation, and glomerulosclerosis and always leads to end-stage kidney diseases (Eid et al., 2013; Sun, Su, Li, & Wang, 2013). Evidences suggest that proliferation of mesangial cells is critical in the initiation and progression of DN (Wolf and Ziyadeh, 1999; Liu et al., 2012;).
The aim of this study is to retrieve a paired epigenetic biomarker signature and the selected autophagy target gene involved in diabetic nephropathy development and progression and to evaluate its usefulness as a urinary molecular marker/s for early diabetic nephropathy detection. Our study included 43 diabetic nephropathy patients, males constituted 31.3% and females constituted 68.8%.