الفهرس 
I- Hepatocellular CarcinomaOnly 14 pages are availabe for public view
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Abstract
Liver cancer in adult men is the fifth most frequently diagnosed cancer worldwide, and is the second leading cause of cancer-related death in the world. The genomic actions of vitamin D are mediated through its binding to the Vitamin D Receptor (VDR). In the current study we planned to evaluate the methylation of vitamin D receptor for the first time in hepatocellular carcinoma, to investigate the possibility that methylation-induced silencing of VDR in Hepatocellular carcinoma might account for the Vitamin D insensitivity.
Subjects were categorized into three groups, Hepatocellular carcinoma, chronic liver lesions diagnosed after exclusion of malignancy by pathology and apparently normal liver. Subjects were recruited from referrals of biopsies. Methylation specific PCR was done on all samples using methylated and unmethylated VDR primers. There was a highly significant difference between the three groups as regard Vitamin D Receptor Gene Promoter methylation percentage, p< 0.01; demonstrating VDR gene promoter methylation as a potential diagnostic biomarker to differentiate between Hepatocellular Carcinoma and other non malignant lesions.