الفهرس 
Chronic RhinosinusitisOnly 14 pages are availabe for public view
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Abstract
Chronic rhinosinusitis (CRS) is one of most common diseases with no specific long life treatment. CRS can be presented in two phenotypes; CRS without nasal polyps (CRSsNP) or with nasal polyps (CRSwNP). Vitamin D (VD) now is considered to have an immunomodulatory role especially in allergic diseases. Recent researches found that patients with CRS have VD level lower than normal, especially in patients with CRSwNP.
Aims: The aim of this study is to systematically evaluate and find out whether there is a relationship between serum VD level and CRS and its phenotypes.
Materials and Methods: Using MEDLINE database, we conducted a systematic search to find all related articles published up to 31 August 2016 using keywords: VD, allergic rhinitis, CRSwNP, CRSsNP with certain inclusion and exclusion criteria.
Results: 6 articles were included with a total number of participants of 309 with serum VD level. Four comparisons were done; the 1st comparison showed no statistically significant difference in VD level between CRSsNP and control group. The 2nd showed a statistically significant lower VD level in CRSwNP than control group. The 3rd showed a statistically significant lower VD level in CRSwNP than CRSsNP. The last one showed no statistically significant difference in VD level between CRS with or without NP and control group.
Conclusions: VD level was significantly low in patients with CRSwNP, which might have a causative relationship. On the other hand there was no relation between VD level and CRSsNP.