الفهرس 
? Living Donor Liver TransplantationOnly 14 pages are availabe for public view
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Abstract
Aim of the work: To assess HLA compatibility, HLA antibodies and cross matching in liver transplantation recipients and their relation to acute rejection, CMV infection, and recurrence of HCV infection
Background: The exact role of HLA compatibility between donor and recipient in organ transplant outcomes has been widely studied. The importance of HLA matching in liver transplantation is controversial, and those grafts, which are carried out without considering HLA matching, present good acceptance and prolonged survival.
Patients and methods: This was a prospective cohort study conducted on 24 patients who had undergone LDLT between January 2015 and January 2016 at in Ain Shams Center for Organ Transplantation (ASCOT), HLA was performed by A SSP-PCR (sequence-specific- primer). HLA-A, HLA- B, and HLA-DR loci were examined and used to calculate mismatch scores. Complement-dependent cytotoxicity cross matching is used at 4° C and 37° C. We also investigated the post transplantation laboratory data, incidence of acute rejection, recurrence of hepatitis C virus (HCV) infection and CMV infection as outcome parameters.
Results: The total HLA mismatch (0-6) so as the type of HLA-A, HLA-B, and HLA-DR mismatch had no effect on Recurrence of HCV infection, CMV infection, and episodes of acute rejection except for HLA A mismatch that showed statistically significant relation with acute rejection with (P value=0.028).So as Complement-dependent cytotoxicity cross matching between donor and recipient showed no effect on recurrence of HCV infection, CMV infection, and episodes of acute rejection.
Conclusion: Mismatching of total HLA or HLA-A, HLA-B, and HLA-DR and positive cross match had no significant impact on recurrence of HCV infection, the incidence of acute rejection or CMV infection and it shouldn’t be routinely used prior to LDLT or as a cause of donor rejection.