الفهرس 
Neonatal SepsisOnly 14 pages are availabe for public view
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Abstract
Neonatal sepsis is one of the major health problems throughout the world, According to WHO approximately 5 million neonatal deaths occur each year worldwide, 98% of which in least developing countries. A variety of factors contributed to this serious disease including maternal risk factors as prematurity and invasive procedures. Sepsis can be considered an abrupt evolution of infections supported by acytokine-mediated condition consisting of immune, inflammatory and coagulation hemostasis impairment. Aim: To evaluate serum level of IL27 in preterm newborn with neonatal sepsis and the relationship between serum IL27 and different laboratory markers for sepsis will be studied. Neonatal sepsis (NS) is a life-threatening disorder and an important cause of morbidity (1 to 10 per 1000 live births) and mortality (15% to 50%) in neonates, especially in preterm. The prevalence of bacterial isolates in blood culture results among neonatal sepsis group: showed that staph aureus, coagulase negative streptococcus (CONS) and Klebsiella Pneumonii (20.8%) were the most prevalent isolated bacteria followed by group B streptococcus and E coli (12.5%) then Acenitoobacter pneumonii (4.2%) and pseudomonas (4.2%). In conclusion, IL-27 can be considered as a novel candidate diagnostic biomarker for predicting neonatal sepsis. However, additional studies will be required to test further the diagnostic performance of IL-27.
Keywords: Interleukin-27- (IL27), Neonatal sepsis, staph aureus, coagulase negative streptococcus.