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Abstract Introduction: Tuberculosis (TB) has existed for long time and remains a major global health problem. It causes ill-health in millions of people each year and in 2015 was one of the top 10 causes of death worldwide, ranking above HIV/AIDS as one of the leading causes of death due to infectious disease. There were 1.4 million TB deaths in 2015 and 10.4 million new TB cases. Aim of the Work: To estimate frequency of mycobacterium tuberculosis infection in adult SLE patients & its relation to disease duration, activity, damage and treatment. Patients and Methods: This cross-sectional study included 100 SLE patients fulfilling the American college of Rheumatology (ACR) revised classification criteria for SLE. All patients were recruited randomly from the Rheumatology outpatient clinic and the inpatient ward of Internal Medicine and Rheumatology department, Ain Shams University hospital. Results: This study is a cross-sectional study that was performed on 100 Egyptian SLE patients fulfilling the American college of Rheumatology (ACR) revised classification criteria for SLE. Summary & Conclusions: In conclusion, 15% of our studied SLE patients had latent TB infection (LTBI) either by using QFT-GIT or TST with poor agreement between the two tests. No cases of active TB had been detected. No association between LTBI and disease duration, activity, damage and used immunosuppressive drugs. |