الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 159 |  |  |
| | | from | 159 | | |
Abstract
The modifying effect of Asperigllus awamori administration is studied during the initiation phase on liver carcinogenesis induced by diethylnitrosamine (DEN) which examined in male wister rats. Aspergillus awomeri is a common fungus isolated from both terrestrial and marine environments, it also produces a diversity of secondary metabolites that are economically significant, such as the antihypercholesterolemic drug and several other metabolites. Seventy-two (72) male Wistar rats were used and randomly allotted into eight different equal groups. Rats in the 1st were administered normal saline by gastric intubation and kept as control negative, the 2nd group received a single dose (200mg/kg) of diethylnitrosamine (DEN) by intraperitoneal (i.p) injection once in first day of experiment, while groups 3th-5th received daily Aspergillus awamori by gastric intubation at a dose 0.1, 0.05 or 0.025 g/kg B.W respectively after a single dose of DEN injection. Groups 6th-8th received daily Aspergillus awamori alone by gastric intubation at a dose 0.1, 0.05 or 0.025 g/kg BW respectively. All rats fed on the same basal diet for one week. It’s observed that that Aspergillus awamori extract administration may be a new alternative medicine for the prevetion of cancer.