الفهرس | Only 14 pages are availabe for public view |
Abstract Cardiovascular disease is one of the main causes of disability and death among men and women all over the world especially in developed countries. Most of these premature mortalities occur in a subgroup of the population that is prone to accelerated atherogenesis caused by genetic, lifestyle, and environmental factors, along with their interactions. Despite many studies and clinical trials have demonstrated the association between multiple risk factors like diabetes mellitus, hypercholesterolemia, male sex, postmenopausal period, disorders of coagulation, homocysteine abnormalities, and coronary artery disease, the need for more detailed studies of other risk factors still mandatory aiming for significant progress in primary prevention and treatment strategies. Vitamin D receptor has been identified on the surface of smooth muscle cells, endothelial cells and cardiomyocytes, but also inflammatory cells, controlling their proliferation and differentiation, and even in platelets, thus potentially influencing thrombosis. Due to the strong relation between vitamin D level and vascular endothelial dysfunction, recent studies started to consider decreased vitamin D level as an independent risk factor for increased blood pressure, insulin resistance, and fatal strokes, the matter that pushed towards more attention as regard the relation between vitamin D level and coronary artery disease. We tried to study the relation between the level of vitamin D and the extent of coronary heart disease. |