الفهرس 
PREECLAMPSIAOnly 14 pages are availabe for public view
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Abstract
Preeclampsia refers to the new onset of hypertension and either proteinuria or endorgan dysfunction or both after 20 weeks of gestation in a previously normotensive woman. Severe hypertension and signs/symptoms of endorgan injury are considered the severe spectrum of the disease.
sFlt-1, VEGF, PIGF- Soluble fms–like tyrosine kinase 1 (sFlt-1 or sVEGFR1) is a naturally occurring, circulating antagonist to vascular endothelial growth factor (VEGF).
The sFlt-1/PIGF ratio may be of value in the prediction of PE and in the differential diagnosis of patients with atypical presentations of preeclampsia, and in the differential diagnosis of women with chronic hypertension suspected to develop superimposed preeclampsia.
The current study is a case control study that was conducted over 90 cases of primigravida patients, 24-34 weeks of gestation, randomly selected patients from outpatient clinic and ER of Ain Shams Maternity Hospital, they were classified into two groups, first group is preeclampsia group which was 45 preeclamptic pregnancies (preeclampsia patients and cases with severe criteria) and the second group was control group which was 45 normal pregnancies.Each patient was examined by sFlt-1/PlGF ratio immunoassay kits.
We analyzed the time to delivery in all 45 patients with PE/HELLP within 2 days (24 patients), 2-7 days (10 patients), and later than 7 days (11 patients). Patients with interval to delivery within 2 days showed a higher sFlt-1/PlGF ratio, the sFlt-1/PlGF ratio in patients delivering within 2 days was (610.85). Patients with interval to delivery within 2-7 days exhibited a sFlt-1/PlGF ratio of (499.7). However, patients delivered later than 7 days had a sFlt-1/PlGF ratio of (230.43).
For all PE/HELLP patients group (24-34 weeks), an sFlt-1/PlGF ratio greater than 590.1 (413.7 – 611.1) is associated with a 11.577 folds increased risk for an immediate occurence of delivery.
The current study has found that the the best cut off point after applying ROC curve between control group and cases group regarding soluble fms like tyrosine kinase/placental growth factor ratio was (> 85) which gave us sensitivity of 100%, specificity of 100% and accuracy of 100%.
Keywords: Role of Soluble FMS-Like, Tyrosine Kinase, Placental Growth Factor, Ratio as Prognostic Marker, Cases of Preeclampsia.