الفهرس 
Recurrent MiscarriageOnly 14 pages are availabe for public view
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Abstract
Figure (1): Classification Of Congenital Uterine Anomalies 16
Figure (2): Rotterdam Criteria And Diagnostic Algorithm Of PCOS. Consensus On Infertility Treatment Related To PCOS 25
Figure (3): Karyotypes Of 2 Women With Recurrent Miscarriage. 29
Figure (4): Megakaryocytes (Above) Which Is Mother Cell Of Platelets (Below) (Sunitha Et Al., 2008). 49
Figure (5): Platelet (Thrombocyte) Formation (Thrombopoiesis) In Bone Marrow 50
Figure (6): Platelets Extruded from Megakaryocytes 51
Figure (7): 3D Rendering Of Platelets 53
Figure (8): Scanning Electron Micrograph Of Blood Cells. from Left To Right 54
Figure (9): Diagram Of The Structure Of A Platelet Showing The Granules 55
Figure (10): Platelet Clumps In A Blood Smear 56
Figure (11): Bar chart Showing Increase MPV (Fl) In Unexplained Recurrent Miscarriage Groups Compared To The Control Group. 93
Figure (12): Bar chart Between Groups According To PDW. 93
Figure (13): Receiver-Operating characteristic (ROC) Curve For Discrimination Between Patients With Unexplained Recurrent Miscarriage And Controls Using Platelet Count. 95
Figure (15): Receiver-Operating characteristic (ROC) Curve For Discrimination Between Patients With Unexplained Recurrent Miscarriage And Controls Using MPV. 97
Figure (16): Receiver-Operating characteristic (ROC) Curve For Discrimination Between Patients With Unexplained Recurrent Miscarriage And Controls Using PDW. 99
Figure (17): Scatter Plot, Negative Correlation And Significant Between MPV And HGB. 102
Figure (18): Scatter Plot, Negative Correlation And Significant Between MPV And HCT. 102
Figure (19): Scatter Plot, Negative Correlation And Significant Between MPV And PLT. 103
Figure (20): Scatter Plot, Positive Correlation And Significant Between MPV And PDW. 103
Association Between Mean Platelet Volume And Unexplained
Recurrent Miscarriage
Abstract
Introduction: According to the Royal College of Obstetricians and Gynaecologists (RCOG), a miscarriage can be defined as the spontaneous loss of a pregnancy before the fetus has reached viability at 24 weeks. This includes all pregnancy losses from the time of conception until 23 completed weeks of gestation. RPL is defined as three or more consecutive miscarriages. The World Health Organization recommends that in developing countries, where gestation is often uncertain, a birth weight of 500 g should be used to define viability. The American Society for Reproductive Medicine defines RPL as two or more failed pregnancies, which have been documented by either ultrasound or histopathological examination. They suggest that some investigation must be done after each miscarriage, with a thorough evaluation after three or more losses.
Aim of the work: The aim of this study is to assess the association between mean platelet volume (MPV) and recurrent miscarriage.
Patients and Methods: Study design: A Prospective observational case control study. Setting: This study was conducted at the recurrent miscarriage clinic in Ain Shams Maternity University Hospital after approval of the Ethical Research committee during the period from April 2016 till January 2017.
Results: In this study there was no statistical significant difference between recurrent miscarriage groups and control group in the haematological parameters of complete blood count including, PDW, Platelet distribution width (%); RDW, Red cell distribution width (%); PCT (x103/mm3): Platelet count Hb, Hemoglobin (g/dl); Htc%, hematocrit; wbc (x103/mm3), white blood cell. While MPV (fl), there is statistically significant difference in the RPL group compared to control group. This study detected significantly higher MPV values in patients with recurrent miscarriage. Our results support the thesis that increased MPV leads to thrombosis, which in turn leads to micro-emboli in the uteroplacental circulation, placental inflammation and insufficiency and consequently recurrent miscarriage.
Keywords: Unexplained recurrent mischarge; Mean platelet volume.