الفهرس 
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Abstract
Clostridial infections are important concern to poultry industry because of severe economic losses and increased mortalities. This study was carried to investigate the current situation of C. Perfringensinfection in broilers and ducks in Damietta governorate, Egypt.A total of 141 intestinal and liver samples were collected from diseased and deadbroiler chickenswith diarrheic chickens (n=129)and ducks (n=12) from private farms to be examined for Clostridium perfringens.The rate of isolation was 48.22% while isolation rate in broiler chickens and ducks was 47.22% and 58.33% respectively .In-vitro sensitivity test was made against different types of antibiotics showing that the examined isolates were highly sensitive to amoxicillin ,ampicillin n and doxycycline.Detection of toxins by animal inoculation by using Guinea pigs and Identification of the isolates using PCR were done .Experimental infection was done in broiler chickens .Signs and post mortumlesions were recorded also reisolation was done as well as histopathological findings were recorded.