الفهرس 
Pathophysiology of Traumatic Brain InjuryOnly 14 pages are availabe for public view
 |  | from | 87 |  |  |
| | | from | 87 | | |
Abstract
Targeted temperature management in traumatic brain injury is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of traumatic brain injury (TBI).
At the clinical level, therapeutic hypothermia (TH) has shown benefits in patients who have suffered cardiac arrest and in some pediatric populations suffering hypoxic brain insults. Also targeted temperature management has long been suggested as a therapeutic strategy after TBI.
Clinical trials evaluating TH after TBI can be divided into two categories, according to the therapeutic aims; trials in which TH was applied in the early phase of traumatic brain injury as prophylactic neuroprotectant and trials in which TH was applied in the late phase of TBI to control elevated ICP.
Additional studies are needed to more clearly define the optimal timing of hypothermia in terms of induction and duration, and the optimal depth, which are likely to be different for each insult. Guidelines will be implemented favoring a greater number of patients to achieve a good outcome.
In this review there is highlight on targeted temperature management in TBI; mechanism of action, techniques used, effects on different body organs, complications.