الفهرس 
Chronic Kidney DiseaseOnly 14 pages are availabe for public view
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Abstract
Recently, it has been shown significant decreases of total serum iron and serum ferritin combined with increases of serum interleukin 6 (IL-6) have been observed in hemodialysis patients treated with oral ferrous sulphate. Bovine lactoferrin (bLf) represents an attractive and promising alternative to ferrous sulphate oral administration. Studies has showed that oral administration of bLf, 30% iron saturated, significantly improved hematological markers, including number of red blood cells (RBCs), hemoglobin, total serum iron, serum ferritin concentrations compared to those treated with ferrous sulphate. Aim: To study the effect of oral bovine lactoferrin on iron deficiency patients with chronic kidney disease stages 2-4. In our follow up clinical study, 45 chronic kidney disease (CKD) pediatric patients who are iron deficient within the pediatric nephrology conservative clinic, children’s hospital, Ain Shams University, were subjected to pravotin (lactoferrin) intervention with monitoring of blood Hb and RBC volume before intervention and after 6 months with regular monthly check of both…and monitoring of Iron profile including serum iron, serum ferritin, total iron binding capacity (TIBC) before and after 6 months of treatment. The current study found that blood Hb and RBC volume significantly increased beginning from first month after oral lactoferrin therapy, serum iron significantly increased six months after intervention, serum ferritin significantly increased six months after intervention, and serum TIBC significantly decreased after intervention. The current study had also shown no significant difference between males and females regarding lab changes 6 months after intervention, lab improvements were significantly lowest among cases with stage IV, followed by stage III and highest among cases with stage II.
Keywords: interleukin 6, Bovine lactoferrin, red blood cells, chronic kidney disease.