الفهرس 
Nonalcoholic fatty liverOnly 14 pages are availabe for public view
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Abstract
BACKGROUND: Research in chronic kidney disease (CKD) suggests that non-alcoholic fatty liver disease (NAFLD) has an obvious role in its pathogenesis. CKD & NAFLD have convergent pathophysiological mechanisms and both have a rising risk of cardiovascular events. Increased renal resistive index (RRI) was found to correlate with the degree of renal impairment in patients with CKD.
OBJECTIVE: To detect the relation between NAFLD and RRI as an indicator of early renal affection and its relation to the disease severity.
METHODS: 150 subjects were divided into 3 groups. group 1 included 50 patients with NASH, group 2 included 50 patients with simple steatosis and group 3 included 50 normal healthy individuals as a control. All patients were subjected to full history taking, clinical examination, routine laboratory investigations and RRI measurement.
RESULTS: RRI was highest in NASH patients with fibrosis (mean=0.74) followed by NASH patients without fibrosis (mean=0.65) followed by patients with simple steatosis (mean=63) and lowest in normal controls (mean=0.61). There were significant positive correlations between RRI and all of age, BMI, Cholesterol, triglycerides, ALT, AST, ALP, GGT and liver fibrosis. By multiple linear regression age and cholesterol as significant independent factors (p < 0.0001), explain significantly variance to RRI. We found that RRI had significant low diagnostic performance in differentiation between groups.
CONCLUSION: RRI has no significant relation with NAFLD. Patients with high cholesterol should be screened for CKD.
KEYWORDS: Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; chronic kidney disease; High cholesterol; Renal resistive index.