الفهرس 
PRETERM LABOROnly 14 pages are availabe for public view
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Abstract
Abstract:
Background Simple, more sensitive markers to predict spontaneous preterm delivery in preterm labor are
needed. The aim of this study is to compare the clinical effectiveness of various serum inflammatory markers
and cervix length for prediction of spontaneous preterm delivery.
Materials and methods We prospectively reviewed medical records of 170 patients hospitalized for preterm
labor (95 with preterm delivery and 75 with term delivery). For all study subjects, hematological markers and
cervix length were recorded on admission. Because neutrophil to lymphocyte ratio (NLR) showed the potential
as a diagnostic marker, we designed a combined marker by dividing cervix length by NLR. The diagnostic and
prognostic accuracy of the combined marker was analysed using multivariate analyses.
Results The levels of combined marker (P < 0.001), neutrophil (P < 0.001), lymphocyte (P = 0.014), NLR
(P < 0.001), C-reactive protein (P < 0.001) and the cervix length (P < 0.001) in preterm delivery group were significantly different from those of term delivery group.
Compared to cervix length or systemic inflammatory markers alone, combined marker showed higher sensitivity (91.34%) and specificity (91.04%) for prediction of preterm delivery.
Conclusions Combined marker could be used as a simple and sensitive parameter for identifying women at risk of spontaneous preterm delivery.
Keywords: Cervix length, neutrophil to lymphocyte ratio, preterm delivery, serum marker