الفهرس 
Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
New Instrumental method for determination of certain Antihyperlipidemic and Antihypertensive drugs:
The thesis is concerned with the analysis of some antihyperlipidemic and antihypertensive drugs through development of sensitive, precise and accurate methods for the determination of the investigated drugs either in the pure form or in their pharmaceutical formulations with low cost depending on the availability of chemicals and equipments. The investigation includes usefulness of spectrophotometer and HPLC.
These drugs include Carvedilol, Valsartan, Candesartan cilexetil, Atorvastatin calcium, Rosuvastatin calcium and Hydrochlorothiazide.
The thesis consists of three main parts: Part I (literature review):
Part I (A) Introduction for the studied drugs:
This part is concerned with the demonstration of chemical structure, physical and pharmacological properties of the studied drugs and also theoretical basic background review on the previous methods of the assay of the cited drugs.
Part I (B) Introduction for the reagents used throughout spectrophotometric methods:
This part enumerates the reagents and dyes used throughout the spectrophotometric methods, their molecular structures and their utilization as chromogens and also shows the concentration of their working solutions.
Part II (Experimental):
This part describes the proposed spectrophotometric methods and it is subdivided into following parts:Part II (A):
This part describes spectrophotometric methods for the determination of atorvastatin calcium and rosuvastatin calcium by para-dimethylaminobenzaldehyde method. The reaction products were measured at λmax 540 nm and 570 nm for both drugs respectively. The proposed method was applied for determination of the cited drugs in some pharmaceutical preparations. The obtained results were compared with those of the reference methods.
Part II (B):
This part is concerned with determination of atorvastatin calcium and valsartan by NQS method. The reaction product was measured at λmax 464 nm and 466 nm for both drugs respectively. The method was satisfactory applied for the determination of the drugs in tablets and the results were compared statistically with reference methods.
Part II (C):
This part describes determination of carvedilol, valsartan and rosuvastatin calcium with bromatometric method using thymol blue and methyl orange. The absorbances were measured at λmax 545 nm and 510 nm for the two dyes respectively. The proposed methods were applied for determination of the cited drug in some pharmaceutical preparations. The obtained results were compared with those of the reference methods.
Part III:
This part describes chromatographic methods and it is subdivided into following parts:
Part III (A):
In this part, an isocratic RP-HPLC method has been developed for simultaneous separation and determination of mixture of carvedilol, candesartan cilexetil and hydrochlorothiazide in their pure forms and pharmaceutical preparations. The separation was carried out on Hypersil gold® C18 (15um, 100 x 4.6mm) column using a mobile phase of methanol: acetonitrile: 0.1% ortho-phosphoric acid (pH 1.8) (35: 50:15, v/ v/v) at ambient temperature. The flow rate was0.8 ml/min and the detection was set at 215 nm. The method was satisfactory applied for the determination of drugs in tablet The, results were compared statistically with reference methods.
Part III (B):
This part describes HPLC method for separtion and determination of carvedilol and atorvastatin calcium in their pure forms and pharmaceutical preparations. The separation was carried out on Hypersil gold® C18 (15um, 100x 4.6mm) column using a mobile phase of methanol: acetonitrile: 0.1% ortho-phosphoric acid (pH 1.8) (40: 45:15, v/v/v) at ambient temperature. The flow rate was 0.6 ml/min and the detection was set at 254 nm. The method was satisfactory applied for the determination of drugs in tablet The, results were compared statistically with reference methods.