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العنوان
Signal joint T-cell Receptor Rearrangement Excision Circle as a Potential Marker for Age Estimation in a Sample of Egyptians/
المؤلف
ElOefy,Omnia Saad ElSayed
هيئة الاعداد
باحث / أمنية سعد السيد العوفي
مشرف / أماني السيد عبد الرحمن
مشرف / نبيل نصيف رزق
مشرف / آية شوقي خاطر
تاريخ النشر
2017
عدد الصفحات
215.p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأمراض والطب الشرعي
تاريخ الإجازة
1/1/2017
مكان الإجازة
جامعة عين شمس - كلية الطب - Forensic Medicine and Toxicology
الفهرس
Only 14 pages are availabe for public view

from 119

from 119

Abstract

Abstract
Age can be determined very accurately in childhood using developmental methods like dental eruption, dimensions of bones, presence of ossification centers and epiphyseal fusion. However, in adults this methodology is less accurate. For that reason, new biochemical and molecular methodologies have been developed.
Biochemical methods are based on the natural process of aging, which including different biochemical changes that lead to age related alterations in cells and tissues. Some methods that could be used in age estimation, such as aspartic acid racemization, collagen content in human teeth, bone and cartilage and lead accumulation in teeth.
Molecular biology approaches analyzed DNA alterations that occur with aging such as age-dependent accumulation of deletions that occur in mitochondrial DNA, telomere shortening and DNA methylation.
Keywords: Reactive oxygen species- revolutions per minute - Severe combined immunodeficiency- Safety Data Sheet- TATA box binding protein - T-cell receptor