الفهرس | Only 14 pages are availabe for public view |
Abstract Serratia marcescens was considered in the past to be a harmless and non-pathogenic organism in humans, it is now becoming an important cause of hospital-associated infections including urinary tract infections, respiratory tract infections, septicemia, wound infections and meningitis. Plasmid-mediated ESBLs which are capable of hydrolyzing the extended spectrum cephalosporins and monobactams are becoming increasingly frequent among clinical isolates of the family Enterobacteriaceae throughout the world. Also, Amp C beta-lactamases which are often plasmid mediated hydrolyze all β-lactam antibiotics except cefepime and carbapenems and confer resistance to cephalothin, cefazolin, cefoxitin, most penicillins and beta-lactam inhibitor combinations (broad multidrug resistance) continue to be a major problem in health care settings. |