الفهرس | Only 14 pages are availabe for public view |
Abstract The development of in-situ gel systems has received considerable attention over the last few years. In the last few years, increasing number of in-situ gel forming systems have been investigated to provide sustained drug delivery. Drugs that are easily absorbed from the GIT and having a short half-life like buspirone HCl (BH) are eliminated quickly from the blood circulation. To avoid these problems, oral controlled drug delivery systems have been developed as they can release the drug slowly into the GIT and maintain a constant drug concentration in the serum for a longer period of time; therefore, they enhance the bioavailability of drugs. Also, the intranasal route has been considered as a viable alternative for drugs which suffer from extensive first pass metabolism like BH. This route is also having an added advantage of direct delivery of drugs to the brain when the site of action is in the brain. Buspirone HCl-loaded niosomes were also formulated in order to increase the nasal absorption of BH. The aim of this thesis is to formulate BH into oral and nasal niosomal in-situ gels to solve the previously mentioned problems. |