الفهرس 
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Abstract
Although CHD mortality rate have declined over the past fourdecades, it still represents the most leading cause of death worldwide(Rosamond et al., 2008, Nichols et al., 2014). Identification, preventionand treatment of risk factors associated with CHD become mandatory toovercome this major health problem (Ridkeret al., 2012). One of the risk factors that still under investigations ishyperuricemia. It’s still debatable whether it’s an independent risk factoror it’s just a consequence of other disorders associated with CVS diseaselike hypertension, diabetes and dyslipidemia (Hozawa et al., 2006). We conducted a prospective study that included 95 patients whounder went coronary angiography at our department between October 2015and October 2016. We used Gensini score for evaluation of the severity ofCAD. We classified patients into two groups being diagnosed as CAD ornot, then we studied the association between CAD and the serum uric acidand the other well-known conventional risk factors through logistic regression analysis aiming to identify the independent predictors of CAD. The main finding in our study is the significant higher mean ± SDserum uric acid levels in patients with CAD versus free patients (6.3±1.6vs 5.5 ± 1.5, P value = .02). When we adjusted the serum uric acid with other significant factors in the univariate analysis which were age, gender and smoking, serum uric acid was an independent risk factor (p value = .04). Another interesting finding is the significant correlation between serum uric acid level and the severity of CAD (p < 0.001, r = 0.35). According to ROC analysis a uric acid level of 6.45 mg⁄ dl was found to be the most appropriate cut-off point with the sensitivity 57% and the specificity 78.5% .Our study had a small sample size that prevented us from performing subgroup analysis, also we didn’t assess the effect on mortality due to the short follow up period; therefore, we recommend further studies with higher sample size and longer follow up period. Conclusion: Higher serum uric acid levels are correlated with the presence of CHD and the severity, further prospective studies with large number of patients and long term follow up are still needed.