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Abstract Infertility is generally defined as one year of unprotected intercourse without conception. Approximately 85-90% of healthy young couples conceive, within one year. Infertility therefore, affects 10-15% of couples and is an important part of clinical practice of most clinicians. PCOS is a common endocrinologic disorder in women characterized by chronic anovulation, hyperandrogenemia and infertility. PCOS affects approximately 4% of women of reproductive age. Ovulation induction is a process of promotion of follicular growth and development.It is different from controlled ovarian hyperstimulation involving use of some of the same medications to stimulate development of multiple mature follicles to increase pregnancy rate. The aim of this work is to compare the role of Clomiphene citrate with dexamethazone versus Letrozole with dexamethazone in improving induction of ovulation in polycystic ovarian syndrome in sixty women with the diagnosis of PCOS; divided into 2 groups: group I includes 30 women who took letrozole and dexamethasone and group II includes 30 women who took clomiphene citrate and dexamethasone. Women’s response of the following parameters was compared in both groups as regard number of follicles, diameter of follicles, endometrial thickness, ovulation rate, pregnancy outcome and occurrence of complications as Ovarian Hyperstimulation Syndrome (OHSS) and multipe pregnancies. In our study, there were statistically significant differences between the studied groups regarding number and diameter of follicles, day of HCG administration, ovulation rate and pregnancy outcome. Also, there was statistically a high significant difference between the studied groups regarding endometrial thickness. |