الفهرس 
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Abstract
Gastro-esophageal reflux disease is an abnormal reflux of gastric contents into the esophagus at least once a week, leading to symptoms such as heartburn, acid regurgitation and esophageal mucosal damage, which may also provoke long-term complications, such as Barrett’s esophagus.
Obesity is due to excessive fat accumulation that may impair health resulting also been linked to complications of GERD including the development from social behavior and environmental and genetic factors. Obesity is a risk factor for gastro-esophageal reflux disease (GERD). It is generally considered that intra-abdominal pressure in obese subjects is involved in the pathogenesis of GERD through acid exposure to the esophagus. Obesity has of BE and EAC.
Recently, visceral fat has been recognized as an endocrine organ that secretes various adipocytokines including adiponectin. Abdominal adipose tissue is biologically active circulating factors secreted from adipose tissue may mediate part of the effect of obesity on the development of Barrett`s esophagus, esophageal adenocarcinoma, or both. Adiponectin is apeptide secreted primarily from visceral adipocytes, for which serum level are inversely associated with obesity. Adiponectin inhibits inflammation, promotes apoptosis, and suppresses proliferation and angiogenesis via multiple potential signaling pathways and deficiency of adiponectin has been associated with a number of epithelial cancers.
The present study was aimed to evaluate serum adiponectin in gastero-oesophageal reflux patients and its correlation with obesity.
The subjects were selected from internal medicine department; outpatient clinic El-Menofiya unit hospital with age ranged from 20-75 years of (31) males and (69) females.
One hundred subjects were included in this study and classified into 3 groups:
group (І): included twenty healthy individual with average BMI, don’t complaining of any G.I.T symptoms serve as control group.
group (ІІ): included forty obese patients with GERD symptoms confirmed by upper endoscopy with BMI > 24kg.
group (ІІІ): included forty non obese patients with GERD symptoms with average BMI and confirmed by upper endoscopy.
All subjects were subjected to the following: Full history taking, physical examinations and laboratory investigation with measurement of serum adiponectin by ELISA.
In the present study no statistically significant difference between groups as regard age and gender but special habits of studied groups like coffee drinking, smoking and NSAID was statistically significant for the development of erosive esophagitis. Anthropometric measurements of studied group shows body mass index statistically significant with GERD. Fasting blood glucose, tri-glyceride, total cholesterol and serum adiponectin were statistically significant among groups.
There were significant negative correlation between endoscopic finding and the following factors: body mass index, hiatus hernia, smoking respectively.