الفهرس 
VITAMIN B12 & FOLIC ACIDOnly 14 pages are availabe for public view
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Abstract
Treatment with most of the commonly used AEDs is associated with reduced folate or vitamin B12 serum levels and is a risk factor for elevated levels of homocystiene which is excitotoxic. It was found that the rate of brain atrophy was higher in epileptic patients with elevated homocystiene. The study is clinical trial study aiming to estimate of folic acid & vitamin B12 serum levels among children with idiopathic epilepsy and find out the effect of their supplementation on seizure control as and the cognitive functions of those patients. Twinty five children with drug resistant idiopathic epilepsy were recruited from Pediatric Neurology Clinic, Ain Shams University. They were subdivided into two groups, group A (on monotherapy of AEDs) and group B (on polytherapy of AEDs). Twenty five age and sex matched healthy children served as controls. All patients and controls subjected to full history including (seizures frequency and Chalfont scale), clinical examination, estimation of vitamin B12 and folic acid in serum and cognitive function tests (WISC). Supplementation of vitamin B12 and folic acid (all patients only) for 3 months followed by reassessment of seizures frequency, Chalfont scale, serum vitamin B12 and folic acid and cognitive function tests. Mean serum vitamin B12 and folic acid was significantly lower in epileptic patients than controls (p<0.001; p<0.001). Patients had significantly lower TIQ, VIQ, and PIQ scores compared to controls (p<0.001; p=0.014; p<0.001, respectively). After 3months of supplementation there was a highly significant increase in both serum vitamin B12 & folic acid in patients group (p<0.001; p<0.001), significant decrease in seizures frequency and Chalfont scale in patients group (p<0.001; p=0.005, respectively) and there was a significant increase in PIQ (p=0.004). Mean VIQ scores was significantly lower in patients on polytherapy compared to those on monotherapy (p=0.034). A negative significant correlation was found between serum Vitamin B12 and either Chalfont scale & seizures frequency. While, a positive significant correlation between serum vitamin B12 and VIQ was detected.