الفهرس 
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Abstract
Henoch–Schönlein purpura is a multisystemic, autoimmune, vasculitic disease which mainly affects the small vessels of skin, joints, gastrointestinal tract, and kidneys that results in a triad of symptoms, including a purpuric rash occurring on the lower extremities, abdominal pain or renal involvement, and arthritis. It is most common in children generally between 2 and 15 years of age with 50% of the cases manifesting before the age of 5 years. Also, it was reported that heart involvement in HSP appears as myocarditis or arrythmia due to vascular damage of coronary arteries and tiny intramyocardial capillaries and also, myocardial affection in systemic vasculitis may occur.
Troponin I (TnI) is a protein present exclusively in the myocardial cells. The TnI plasma concentration is a well-established specific and sensitive marker of myocardial injury, with both high diagnostic and prognostic value. Also, the myocardial band (MB) isoenzyme of creatine kinase (CK-MB) is the biochemical marker currently used for the evaluation of patients with suspected acute myocardial infarction ”CK-MB mass immunoassays are able to measure small changes during the early hours following the onset of acute MI”. The abnormal levels of Troponin I and creatinine kinase-MB isoenzyme may indicate vasculitic cardiac involvement.
This study is a prospective one included 20 pediatric cases diagnosed as Henoch-Schönlein purpura admitted to Abu-el Reesh hospital with age range (3-12 years) from October 2016 to Mars 2017. The study protocol was approved by ethics Clinical Research Ethics Committee and the Institutional Review Board of faculty of medicine, Beni-Suef University. The objective of this study is to assess myocardial function in Henoch-Schönlein purpura by measuring Troponin I (cTnI) and myocardial band of isoenzyme creatine kinase (CK-MB).
The results are summarized as follows:
The mean age of cases was 6.8 years (3-12) and 12 cases (60.0%) were males however, the rest 8 cases were females.
All of cases (100.0%) had lower limbs rash. Heart rate was 99.8 bpm, systolic blood pressure was 103.7mmHg, diastolic blood pressure was 65.0 mmHg. Joint pain was presented in 11 cases (55.0%) and abdominal pain in 11 cases (55.0%).
Abdominal Ultrasound was normal the majority of cases (19 cases, 95.0%).
ECG findings were normal in all cases. While, ECHO findings was normal in about 13 cases (65.0%) of them and IVS and LVPW were normal in 13 cases (65.0%).
IVS and LVPW were normal in 13 cases and above normal in 7 cases (35.0%). The mean of GFR was 95.1.
Regarding CBC results, Normal cases were 8 (40.0%) and 4 cases (20.0%) had anemia, Lekocytosis was found in 3 cses (15.0%) and high platelets count was noticed in 5 cases (25.0%).
Urine analysis was normal in 5 cases (25.0%), Urates was found in 4 cases (20.0%), Uric acid was high in 6 cases (30.0%), PUS cells was found in 1 case (5.0%), however, RBCs was found in 1 case (5.0%), Oxalates was noticed in 3 cases (15.0%).
Kidney function test was normal in all cases and the mean of GFR was 95.1.
Troponin I (cTnI) level was abnormal in 5 cases (25.0%) and was normal in 15 cases (75.0%). While, Creatine kinase (CK-MB) level was Abnormal in 2 cases (10.0%) and normal in 18 cases (90.0%).