الفهرس 
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Abstract
Recently, considerable attention has been focused on the development of new drug delivery systems. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. This thesis comprises the following two parts: The first part deals with Formulation of Ketoconazole Solid Dispersion Using Phospholipid Carriers. The second part deals with Potential Use of Acitretin-Loaded Niosomes for Effective Topical Treatment of Psoriasis.This thesis consists of two parts: Part I: The goal of work in this part was to investigate the potential use of solid dispersion (SD) as a LBDDS in the following manner:Preparation of ketoconazole (KET) SDs employing phospholipid carriers namely; dimyristoylphosphatidyl glycerol (DMPG) and dipalmitoylphosphatidyl choline (DPPC) either alone or in combination with other hydrophilic carriers such as polyethylene glycol 4000 (PEG 4000) and poloxamer 188. characterization of the drug/carrier combination(s) using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) as well as the in vitro dissolution behavior at various physiological pH values. Studying the potential of the SD formulations for oral bioavailability enhancement of KET using rabbitsas animal model. Part II: The main goal for the study in this part is the: Preparation of Act-loaded niosomal formulations using different molar ratios of span 60 and cholesterol.Evaluation of the niosomal formulations with respect to their particle size, zeta potential, entrapment efficiency and ex vivo skin permeation behavior. Investigation of the in vivo anti-psoriatic activity of Act-niosomal gel using mouse tail model in comparison with Act gel and commercial product (Zarotex gel 0.1%) in treatment of psoriasis after topical application once daily for 4 weeks to mice. Assessment of skin safety of different gel formulations. The thesis comprises two main parts including 196 pages, 397 references, 41 figures, 15 tables and ends with Arabic summery.