الفهرس 
Systtemiic Lupus ErytthemattosusOnly 14 pages are availabe for public view
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Abstract
SLE is a heterogeneous, chronic, episodic and multisystem autoimmune disease associated with severe organ damage. SLE etiopathogenesis is a vicious cycle of autoantigen exposure, autoantibody production, chronic inflammation and tissue damage. SLE is generally considered a multifactorial disease, as a combination< of genetics, environmental triggers, sex hormones and other factors. Although the precise pathogenesis of SLE remains unclear, overactivation or hyperproliferation of T and B lymphocytes and abnormal immune tolerance are considered to be some of the main causes. Also deregulated cytokine production contributes to immune dysfunction and mediates tissue inflammation and organ damage.