الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 107 |  |  |
| | | from | 107 | | |
Abstract
Preeclampsia (PE) is a severe pregnancy-associated condition characterized by elevated blood pressure and proteinuria with onset after 20 weeks´ gestation .
BDNF is a neurotrophins, plays an important role in proliferation, differentiation and survival of neurons during development.
Many studies performed to correlations between BDNF in maternal blood and umbilical cord blood under physiological conditions.
Other studies, focussed on differences in BDNF levels between PE and non-PE cases.
Children born to mothers with preeclampsia have consistently been suggested to be at risk for cognitive and behavioral disorders in later life.
In our study we aim to estimate the level of brain derived neurotrophic factor in breast milk of mothers suffering from preeclampsia and in serum of their newborns and assess the correlation between milk level of BDNF in both preeclamptic and normal mothers and its serum levels of their infants .
The current study was carried out on 50 mothers and their newborns aging between 5-10 days old selected from Minia University Pediateric Hospital from March 2015 to Augest 2015.
The patient group include 35 mothers suffering from preeclampsia and their infants aging 5-10 days .
The control group include 15 non preeclamptic mothers and their infants aging 5-10 days .
All the neoborns were subjected to Complete history taking ,Clinical examination including general and systemic examinations , Laboratory investigation including level of of BDNF in breast milk of mothers and serum of their newborns by using ELIZA technique .
In our study we indicate that :
There was no significant difference between cases and control as regard maternal age , gestational age , mode of delivary and parity .
There was highly significant difference increase of the body mass index , systolic and diastolic blood pressure and weight of mothers suffering from preeclampsia .
There was no significant difference between cases and control as regard Maternal lenghth .
There was highly significant difference decrease in the weight and neonatal ponderal index in infants of mothers suffering from preeclamptic mothers .
There was no significant difference between cases and control as regard neonatal lenghth , sex , head circumference , chest circumference and abdominal circumference .
There was highly significant decrease in serum BDNF in infants of preeclmptic mothers
There was highly significant increase in BDNF in breast milk of mothers suffering from preeclampsia.