الفهرس 
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Abstract
The present study was investigated the hematological, immunological, biochemical and histopathological alterations induced by Aspirin and Meloxicam in healthy male albino rats, as well as, to investigate the effects of combined administration of vitamin C with Aspirin or Meloxicam in modulation of these alterations.. Fifty-four male albino rats (140-160 g) were divided into nine groups. The first group (control) was given orally 1 ml/kg of saline solution. Second and third groups were given orally 50 and 150 mg/kg of Aspirin, respectively. Forth and fifth groups were given orally 2 and 6 mg/kg of Meloxicam, respectively. Sixth and seventh groups were given orally 50 and 150 mg/kg of Aspirin along with vitamin C (200 mg/Kg), respectively. Eighth and ninth groups were given orally 2 and 6 mg/kg of Meloxicam along with vitamin C (200 mg/Kg), respectively. The obtained results showed that Aspirin at both doses induced significant increases in RBCs, monocytes count, Hb, PCV%, platelets, serum IgG, creatinine, AST and ALT and decreases in neutrophils, lymphocytes count and serum IgM level. Meloxicam at both doses induced significant increases in total WBCs, monocytes count, Hb, platelets, serum creatinine, TC, LDL-C, AST, ALT and MDA, and decreases in neutrophil counts, HDL-C and SOD. Moreover, high dose of Aspirin or meloxicam showed significant histopathological alterations in liver and kidney. Co-administration of vitamin C and Aspirin or Meloxicam intoxication attenuated the severe hematological, immunological and biochemical alterations induced by Aspirin. We concluded that Aspirin and Meloxicam caused hepatotoxic and nephrotoxic effects and supplementation with vitamin C could counteract their toxic effects. Aspirin affected both cell-mediated and humoral immunity, but, Meloxicam affected only cell-mediated immunity and vitamin C could exert immunomodulatory action.