الفهرس 
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Abstract
Osteoarthritis is a leading cause of disability in developed countries , it is the most common joint disease, with millions of affected individuals worldwide. The knee joint is one of the the most common sites of involvement. In the 65- to 75-year age group, radiological knee osteoarthritis is present in 35% of women and 20% of men. Progression of the disease is marked by destruction of the joint cartilage, sclerosis of the underlying bone, and formation of osteophytes at the joint margin.26
No targeted treatments for osteoarthritis have been developed. Recommendations for osteoarthritis management include the administration of medications designed to alleviate the symptoms and to improve joint function. None of these medications can eventually prevent the progression of the disease. Eventually, surgery may become necessary, the most common procedure is total knee replacement.27
Platelet-rich plasma (PRP) is the volume of the plasma fraction of autologous blood having a platelet concentration above baseline. The properties of PRP are based on the production and release of multiple growth and differentiation factors when the platelets are activated after intra-articular injection.59
Thirty patients (12males- 18 females) with mild to moderate knee osteoarthritis were treated in Beni Suef university hospital. Their ages range from 37 to 65 years with a mean (49.13 years). Each patient was injected with intra-articular autologous platelet-rich plasma in his affected knee; injection was done twice at four weeks interval.
The present study showed that intra-articular PRP injection is a simple, low-cost therapy and minimally invasive method that can be used to enhance tissue regeneration. Thus, it reduced pain and improved knee function and quality of life in patients with mild to moderate degree of osteoarthritis.