الفهرس 
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Abstract
Doramectin is a potent 2nd generation endectocide. The present study was carried out to investigate the possible adverse effects of a single therapeutic (TD) and double therapeutic doses (DTD) of doramectin on sperm picture, serum total testosterone level, testicular oxidative stress and antioxidant defense markers, index weight of testes and epididymis in male rats. Moreover, histopathological examination of testes, epididymis and seminal vesicle was applied, with special references to their effects on some hematological parameters. Seventy two clinically healthy mature male Sprague Dawley rats (12 weeks old and 200-300g body weight) were used in this study. Rats were randomly divided into 3 equal groups (each of 24 rats) as follows: a- First group (control): injected with sesame oil subcutaneously as a single dose. b- Second group: injected with a single therapeutic dose of doramectin (200µg/kg b.wt) subcutaneously. c- Third group: inject with a single double therapeutic dose of doramectin (400µg/kg b.wt) subcutaneously. The obtained results revealed that the index weight of testes in treated rats was significantly decreased at 1st, 2nd, 4th and 8th weeks post treatment by both TD and DTD of doramectin also the epididymal index weight only at 4th week. Moreover, there were significant decreased in sperm cell concentration at 2nd, 4th and 8th weeks post treatment with both doses, live sperms % at 4th and 8th week post treatment with both doses but in 2nd week only with the DTD, the levels of total serum testosterone hormone along the whole experimental period and testicular GST activity at 4th week post treatment with both doses and in 8th week post treatment with DTD. On the other hand, the percent of total sperm abnormalities, testicular NO activity and testicular MDA activity were increased significantly at 4th and 8th week post treatment by both TD and DTD of doramectin. Blood picture showed significantly decrease in RBCs count, Hb concentration and PCV % at the 2nd week post treatment with DTD of doramectin, and also at 4th week in RBCs count and PCV%. Moreover, the WBCs count was significantly decreased in DTD treated group at the 1st and 4th weeks also platelets count was significantly decreased at 2nd week in both treated group. However, there were a significant increase in MCV at 1st week in TD treated group and at 4th week in DTD treated group also in MCHC and platelets count at 1st week post treatment with TD and DTD of doramectin. Doramectin induced significant alterations in testes and epididymis with both TD and DTD. Moreover, the mean johnsen scores were significantly decreased at 4th week with DTD of doramectin and at 8th week with both doses. It could be concluded that, doramectin whether by therapeutic or double therapeutic doses to mature male rats induces hazardous effects on male fertility as well as, some changes in hematological picture.