الفهرس 
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Abstract
Background
APS is an autoimmune thrombophilic condition occurring due to the presence of antibodies that recognize phospholipid binding proteins (aPLs), It can be a primary disease (PAPS) and can occurin association with other autoimmune diseases (ARD/APS).
Aim of the work
To evaluate the clinical and immunological manifestations of APS
Patients and Methods
A total of 70 patients with APS were included in the study, they were subjected to detailed medical and obstetric history,full clinical and rheumatologic examinations, and laboratory investigations including; CBC, ESR, CRP, Lipid profile, ANA, Anti-ds DNA, LA, aCL, anti-b2GPI IgM and IgG
Results
The most common clinical manifestations were late abortion, DVT, stroke and thrombocytopenia. LA and anti-b2GPI significantly associated obstetric complications, arterial thrombosis, and thrombocytopenia. Triple aPLs positivity significantly associated thrombotic events and no significant differences were found between PAPS and ARD/APS.
Conclusions/interpretation: There was a significant association between presence of certain aPLs and occurrence of certain clinical complications especially at certain cutoff values.