الفهرس 
ApocyninOnly 14 pages are availabe for public view
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Abstract
Apocynin (4-hydroxy-3-methoxyacetophenone) which isolated from the traditional medicinal plant Picrorhiza kurroa, is a naturally occurring methoxy-substituted catechol, experimentally used as an inhibitor of NADPH oxidase and of the concomitant ROS production. Apocynin also proved to be a potent anti-inflammatory agent, based on the selective inhibition of the production of ROS by activated human PMNs.
The present work was performed to evaluate the protective effect of apocynin on kidney function in rat with renal injury induced by renal I/R and its possible underlying protective mechanisms.
Forty male rats were used in this study and divided into four equal groups (ten rats each).
group I (Sham- operated group):
The animals of this group were underwent a midline laparotomy incision and then exposure of the two pedicles of both kidneys and then closure of incision.
group II (Renal I/R group):
The animals of this group received normal diet and tape water along the period of experiment. Then both renal arteries and veins occluded together by a traumatic clamp for 60 minutes of ischemia. Following 60 minutes of ischemia, a reperfusion period for the rest of 24 hours was done by removing the clamp.