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Abstract positron emission tomography (PET) using fluorodeoxyglucose (FDG) with computed tomography (CT) has proved effective as a metabolic imaging tool with compelling evidence supporting its superiority over conventional modalities, particularly in staging and early evaluation of response (Kostakoglu & Cheson.,2014). PET/CT scanning after completion of therapy should be performed within two months and preferably at six to eight weeks after chemotherapy (Chiewvit et al., 2014). Indications of PET/CT in NHL *Diagnosing malignancies (differentiate benign from Malignant lesions). *Staging and restaging of NHLs. *Monitor therapy: Early and after completion of treatment. *Assess early relapse. Moreover, an important and valid application of PET/CT is to detect viable tumor in residual lesions after the treatment of patients NHL. A residual mass at the end of therapy is not a rare finding and is considered a clinical challenge in NHL restaging. FDG-PET has proved to be much more accurate in distinguishing fibrosis from viable tumor, since fibrosis does not show high metabolic activity in contrast to viable residual tumor (Buchpiguel CA .,2011 |