الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 54 |  |  |
| | | from | 54 | | |
Abstract
Congenital heart diseases are the most common cause of major congenital anomalies. There are approximately 1.5 million new cases of CHDs per year worldwide.
In approximately 90% of CHDs cases, the cause is multifactorial, these etiologies, especially inherited causes, have become better understood only in the past 10 years. Although advances in understanding genetic risk factors have been made, little is known regarding non genetic risk factors for the development of CHDs.
Prevention of CHDs has been limited by a lack of information about modifiable risk factors for abnormalities in cardiac development.
The aim of the present work was to assess noninherited risk factors in infants and children with acyanotic congenital heart diseases.
Three hundred children were enrolled in this study divided in two groups as follows:
group (A): 200 patients with acyanotic congenital heart diseases.
group (B):100 subjects as a control group with no heart or genetic disease
All children were under age of two years.
All children were subjected to:
1. History taking: through questionnaire (Appendix 1) to identify any possible hereditary, parental and environmental risk factors during pregnancy.
2. Clinical examination with emphasis on cardiac examination and any abnormal morphologic feature or anomalies.
3. Detailed recent echo cardiographic study done within the previous 6 months prior to the study.
4. Oxygen saturation using pulse oximeter.
The present study showed that
Numerous factors and exposures have been examined for their role in the development of CHDs. significant associations between multiple risk factors and CHDs have been identified.
- There was no significant difference between the studied groups regarding sex, Birth weight, Threatened abortion, GDM, occupational exposure, maternal smoking, paternal smoking and maternal intake of drugs (analgesic antipyretic, antibiotics. antiemetic, antihistaminic, NSADIS, bronchodilators and thyroid hormones).
- There was significant difference between the studied groups regarding Gestational age, parity, previous abortion, mode of pregnancy, DM 1, DM 2 , Hypertension , pre-eclampsia, febrile illness (1st and 3rd trimesters), BMI above 30, mental stress (1st trimester), low socioeconomic level , maternal intake of antihypertensive and lack of intake of maternal folate.