الفهرس 
? Portal HypertensionOnly 14 pages are availabe for public view
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Abstract
Portal hypertension is an abnormal elevation in the blood pressure within the portal circulation which is caused by a functional resistance to blood flow at any part of portal venous system and also increase in the blood flow of the portal venous system.
This study was conducted to evaluate the relevance between the malondialdehyde (MDA) level and portal hypertension in cirrhotic patients and to reveal the potential role of MDA as an important non-invasive diagnostic method in cirrhotic patients with portal hypertension.
To fulfill the aim of this study, sixty participants were included. They were admitted to Tropical Medicine Department, Ain Shams University Hospital
The sixty participants were divided to: group A: thirty cases of cirrhotic patients child A or early B with portal hypertension, All diagnoses were confirmed by labs, ultrasonography, liver biopsy or fibroscan. Our essential diagnostic criteria of portal hypertension depended on study the presence of splenomegaly demonstrable by ultrasound, patent extrahepatic portal vein with frequent collaterals demonstrable by ultrasound and presence of esophageal varices by endoscopy (with or without variceal bleeding). group B: thirty healthy controls
Results of the current study showed that the mean level of MDA among the studied patients was (228.50 ± 136.20) which is statistically significant higher than the mean level of MDA among the control group which was (30.37 ± 18.73) with p-value < 0.001. Also we found that the best cut off point for MDA in prediction of patients with chronic liver disease with portal hypertension found > 45nM with sensitivity of 100%, specificity of 90%.
As regard clinical presentation, 7 (23.3%) patients presented with jaundice, 26 (86.7%) had a history of UGI bleeding and 9 (30%) presented with abdominal enlargement.
As regard abdominal examination, 10 (33.3%) patients had hepatomegaly, 30 (100.0%) patients had splenomegaly and 9 (30%) patients had ascites.
As regard abdominal ultrasound findings, 10(33.3%) patients had hepatomegaly, 30(100.0%) patients had splenomegaly, 6(20%) patients had moderate ascites, 3(10%) patients had mild ascites and 20(66.7%) patients had abdominal collaterals.
Results of our study also revealed that the severity of liver cirrhosis determined by Child Pugh’s classification affecting level of MDA since the plasma MDA level increased significantly with advanced Child Pugh score, Also MDA level have positive relativity with the width of main portal vein.
Finally the increased plasma MDA level may strongly correlate with hemodynamic disorder and portal hypertension in cirrhotic patients. The result can lead MDA into an important non-invasive diagnostic marker of portal hypertension in cirrhotic patients.